Forget the heal for cancer, heart disease, Alzheimer, or diabetes. Unless …

If you wish a cure for cancer, heart disease, Alzheimer, or diabetes, do not count on the academia, the National Institute of Health (NIH), or the biotech/pharmaceutical industry.  With all the money they have spent on researching these diseases, they need very very little to indicate for it.

In 1971, throughout the State of the Union address, President Nixon declared the war on cancer proposing “an intensive campaign to search out a cure for cancer.”  Since 1971, Americans spent, through taxes, donations, and personal R&D, about $200 billion in inflation-adjusted dollars.  This money made 1.fifty six million papers on cancer. Yet, nowadays we are not any closer to a cure than we tend to were in 1971.  Why?

Consider what Dr. Almog said in his paper: Drug Industry in “depression” (Almog, D. Drug trade in “depression”. Med Sci Monit. 2005 Jan;11(1):SR1-4, I might urge you to read his paper, it’s an eye fixed opener on relationship between academic research and commercial drug discovery): “When the essential science/biology of disease isn’t out there, no new medicine come back to market.” With the billion of greenbacks spent by the NIH on basic science, and the legion papers printed on the subject, the question is, “Why isn’t the basic science/biology of disease obtainable? Individual discoveries within the biology of human disease are cornerstone in new treatments. But, in drug discovery, these basic science/biology discoveries are seemingly unrelated dots. To connect the dots you wish a theory. The Blind Men and also the Elephant may be a famous story concerning six blind men encountering an elephant for the first time. Every man, seizing on the single feature of the animal, that he appeared to possess touched initial, and being incapable of seeing it whole, loudly maintained his restricted opinion on the character of the beast. The elephant was thought of a wall, a spear, a snake, a tree, an acquaintance or a rope, relying on whether or not the blind men had initial grasped the creature’s side, tusk, trunk, knee, ear or tail. The story epitomizes the matter of the reductionist approach in biology. A recent book Microcompetition with Foreign DNA and the Origin of Chronic Disease, by Hanan Polansky [11], presents an alternative. The book identifies the disruption that causes atherosclerosis, cancer, obesity, osteoarthritis, type II diabetes, alopecia, sort I diabetes, multiple sclerosis, asthma, lupus, thyroiditis, inflammatory bowel disease, rheumatoid arthritis, psoriasis, atopic dermatitis, graft versus host disease, and different chronic diseases, and describes the sequence of events that leads from the disruption to the molecular, cellular, and clinical effects.”

What are the implications of the NIH failure?  A decline in the quantity of latest medication introduced by pharmaceutical companies. Think about what professor Taylor says in his paper: Fewer new medicine from the pharmaceutical trade (Taylor D. Fewer new drugs from the pharmaceutical industry. BMJ. 2003 Feb 22;326(7386):408-9): “In 2002 spending on medicines exceeded $400bn (£248bn; 377bn) worldwide. Optimists in the pharmaceutical business believe that the global marketplace for their products will last expanding by around 10% a year, with the United States continuing to guide towards higher per capita outlays. Expenditure on research by the pharmaceutical trade is additionally increasing worldwide. It’s now over $45bn a year—twice the add recorded at the start of the 1990s—and projected to rise to $55bn by 2005-6. Considerations are growing, but, regarding the productivity of research being funded by the most important pharmaceutical companies. … Empirical proof indicates a crisis in productivity in pharmaceutical research. The number of medicines introduced worldwide that contain new active ingredients dropped from a median of over 60 a year within the late 1980s to 52 in 1991 and only 31 in 2001. The general variety of recent active substances undergoing regulatory review continues to be falling.”

On the one hand, the expenditure on analysis is increasing.  On the other, the number of recent medication is decreasing.  The professionals call this example the productivity crisis in drug discovery.

The NIH failed to produce the so a lot of required biology of chronic disease as a result of it’s caught within the reductionist mentality.  Dr. Hanan Polansky offers an alternative.  If we tend to wish a cure for cancer, heart disease, Alzheimer, or diabetes, we want to significantly contemplate his alternative.

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